Go to https://qualitylifeforum.weebly.com/2025-feb-intermittent-fasting-update.html for full text
Part I - Exploratory Discussions
Is intermittent fasting a viable option for weight loss?
Most weight loss researches are focusing on what to eat or not to eat,
metabolic rate, calorie intake vs. energy expenditures, etc; but not
much on when to eat and frequency of intakes. Furthermore, do humans
need to be fed 3 times a day and nibbles in between? Lions in the wild
can go days without food and gorge in up to 66 pounds of meat at one setting is rather normal.
Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect of diet, the frequency and circadian timing of meals, and potential benefits of intermittent periods with no or very low energy intakes. The most common eating pattern in modern societies, three meals plus snacks every day, is abnormal from an evolutionary perspective. Emerging findings from studies of animal models and human subjects suggest that intermittent energy restriction periods of as little as 16 h can improve health indicators and counteract disease processes. The mechanisms involve a metabolic shift to fat metabolism and ketone production, and stimulation of adaptive cellular stress responses that prevent and repair molecular damage. As data on the optimal frequency and timing of meals crystalizes, it will be critical to develop strategies to incorporate those eating patterns into health care policy and practice, and the lifestyles of the population.
Few recent scientific studies suggest that there is great potential for adulthood lifestyles that incorporate periodic fasting to promote optimal health and reduce the risk of many chronic diseases.
Animal studies have documented robust and replicable effects of fasting on health indicators including greater insulin sensitivity, and reduced levels of blood pressure, body fat, IGF-I, insulin, glucose, atherogenic lipids and inflammation. Fasting regimens can ameliorate disease processes and improve functional outcome in animal models of disorders that include myocardial infarction, diabetes, stroke, Alzheimer ’s disease and Parkinson’s Disease. One general mechanism of action of fasting is that it triggers adaptive cellular stress responses, which result in an enhanced ability to cope with more severe stress and counteract disease processes. In addition, by protecting cells from DNA damage, suppressing cell growth and enhancing apoptosis of damaged cells, fasting could retard and/or prevent the formation and growth of cancers.
Recently studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity in part by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
Research studies have shown that reducing your daily caloric intake by 20 to 40 percent is an effective way to lose weight and improve cardiovascular and metabolic health. However, it’s very difficult to eat less every day for a long time. So people are looking for more manageable ways to improve their health, and many are turning to intermittent fasting — short periods of eating little to no energy-containing food and drink.
Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect of diet, the frequency and circadian timing of meals, and potential benefits of intermittent periods with no or very low energy intakes. The most common eating pattern in modern societies, three meals plus snacks every day, is abnormal from an evolutionary perspective. Emerging findings from studies of animal models and human subjects suggest that intermittent energy restriction periods of as little as 16 h can improve health indicators and counteract disease processes. The mechanisms involve a metabolic shift to fat metabolism and ketone production, and stimulation of adaptive cellular stress responses that prevent and repair molecular damage. As data on the optimal frequency and timing of meals crystalizes, it will be critical to develop strategies to incorporate those eating patterns into health care policy and practice, and the lifestyles of the population.
Few recent scientific studies suggest that there is great potential for adulthood lifestyles that incorporate periodic fasting to promote optimal health and reduce the risk of many chronic diseases.
Animal studies have documented robust and replicable effects of fasting on health indicators including greater insulin sensitivity, and reduced levels of blood pressure, body fat, IGF-I, insulin, glucose, atherogenic lipids and inflammation. Fasting regimens can ameliorate disease processes and improve functional outcome in animal models of disorders that include myocardial infarction, diabetes, stroke, Alzheimer ’s disease and Parkinson’s Disease. One general mechanism of action of fasting is that it triggers adaptive cellular stress responses, which result in an enhanced ability to cope with more severe stress and counteract disease processes. In addition, by protecting cells from DNA damage, suppressing cell growth and enhancing apoptosis of damaged cells, fasting could retard and/or prevent the formation and growth of cancers.
Recently studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity in part by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
Research studies have shown that reducing your daily caloric intake by 20 to 40 percent is an effective way to lose weight and improve cardiovascular and metabolic health. However, it’s very difficult to eat less every day for a long time. So people are looking for more manageable ways to improve their health, and many are turning to intermittent fasting — short periods of eating little to no energy-containing food and drink.
A scientific study finding, which published on Nature Medicine, 2025, reported intermittent fasting is effective for weight loss and improves cardiovascular health in people with obesity problems.
Part II - Intermittent Fasting Methods, Guidelines and Practical Tips
Part
III – Key Points and Considerations
Caution –Studies of fasting regimens have not been performed in children, the very old and underweight individuals, and it is possible that fasting would be harmful to these populations. Therapeutic fasting should be under close medical supervision. As clinical data on intermittent fasting for weight loss is very limited to date, consult your personal physician for your nutritional needs and weight management.
References:
The scientific approach to intermittent fasting, 2016, by Dr. Michael VanDerschelden
The complete guide to fasting, 2016, by Jason Fung, MD and Jimmy Moore
http://www.pnas.org/content/111/47/16647.full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/
http://scopeblog.stanford.edu/2016/07/07/intermittent-fasting-fad-or-science-based-diet/
https://sciencebasedmedicine.org/intermittent-fasting/
http://easacademy.org/trainer-resources/article/intermittent-fasting
https://www.sciencedaily.com/releases/2025/01/250108144146.htm
